diff --git a/reference-apps/fastapi/requirements.txt b/reference-apps/fastapi/requirements.txt
index 7cc98ab..fe6995f 100644
--- a/reference-apps/fastapi/requirements.txt
+++ b/reference-apps/fastapi/requirements.txt
@@ -10,7 +10,7 @@ httpx==0.28.1
 # Database drivers
 asyncpg==0.31.0
 aiomysql==0.3.2
-cryptography>=41.0.0  # Required for MySQL caching_sha2_password auth
+cryptography>=50.0.1  # Required for MySQL caching_sha2_password auth
 motor==3.7.1
 pymongo==4.16.0